Guanfacine ER (Intuniv ER)
Online Prescription for ADHD Support
Guanfacine is a medication that belongs to a class called alpha-2 adrenergic agonists. It was originally developed to treat high blood pressure, but lower doses are now widely used in psychiatry and behavioral health. Guanfacine is available in:
Extended-release (ER) form, commonly known by the brand name Intuniv
Immediate-release (IR) form, sometimes used off-label depending on symptoms
The extended-release version is most often prescribed for ADHD.
What is guanfacine used for?
Guanfacine may be prescribed to treat:
ADHD, particularly symptoms related to impulsivity, hyperactivity, and emotional dysregulation
ADHD with co-occurring anxiety or sleep difficulties
Irritability or aggression in certain clinical situations
Guanfacine may be used alone or alongside stimulant medications, depending on an individual’s treatment plan.
How does guanfacine work?
Guanfacine works by affecting alpha-2 receptors in the brain, particularly in areas involved in attention, impulse control, and emotional regulation. By strengthening signals in these brain regions, guanfacine can help:
Improve focus and attention
Reduce impulsive behavior
Support emotional control
Unlike stimulant medications, guanfacine does not increase dopamine levels and works through a different neurological pathway.
What benefits might people notice?
People taking guanfacine may notice benefits such as:
Improved ability to focus and follow instructions
Reduced impulsivity or hyperactivity
Better emotional regulation
Less reactivity or irritability
Improvements often happen gradually and may become more noticeable over several weeks.
Possible side effects
Guanfacine is generally well tolerated, but side effects can occur. Commonly reported side effects include:
Drowsiness or fatigue
Dizziness
Dry mouth
Headache
Lower blood pressure or slower heart rate
Because guanfacine can cause drowsiness, it is often taken in the evening, especially when first starting treatment.
How is guanfacine taken?
Guanfacine is typically taken once daily, especially in its extended-release form. It should be taken consistently at the same time each day. Extended-release guanfacine tablets should not be crushed or chewed, as this can affect how the medication is absorbed.
How does guanfacine compare to stimulant medications?
Guanfacine differs from stimulant ADHD medications in several ways:
It is non-stimulant
It does not typically suppress appetite to the same degree
It may be especially helpful for emotional regulation and impulsivity
Because of these differences, guanfacine may be considered when stimulants are not tolerated or when additional symptom control is needed.
Insurance coverage and access
Guanfacine and its generic forms are covered by most major insurance plans. Generic guanfacine, including extended-release versions, is widely available and generally affordable.
What to consider when researching guanfacine
If you are exploring guanfacine, it may help to consider:
Which ADHD symptoms are most challenging
Whether sleep, anxiety, or emotional regulation are concerns
Whether stimulant medications have caused unwanted side effects in the past
These considerations can help guide discussions with your psychiatric provider.
Disclaimer: Medication decisions are made by a licensed psychiatric provider based on a clinical evaluation, medical history, and individual needs. Not every medication is appropriate for every person, and treatment options should be discussed directly with your provider before starting or changing medication.